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Senior Director, Vonjo, Core Asset Team (CAT) Lead

usPosted 15 Sept 2026

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About this role

Role Summary The Vonjo Core Asset Team (CAT) Lead is a senior cross-functional lead accountable for defining and executing the global strategy for Sobi's Vonjo portfolio, including its established myelofibrosis indication and pipeline expansion opportunities. This includes label expansion in myelofibrosis, development of a new indication and global program for VEXAS, lifecycle management (LCM), regulatory and commercial readiness, and long-term value maximization across key global markets — with the U.S.

as the lead focus. The role orchestrates an integrated strategy and execution plan to ensure successful development, approval, geographic expansion, and sustained global growth of Sobi's Vonjo asset. Reports to: Vice President, US Hematology Key Responsibilities Strategic Leadership Define and lead the global asset strategy for Vonjo, aligned with corporate priorities, spanning myelofibrosis label expansion and the emerging VEXAS indication.

Develop and maintain a high-quality Integrated Project Plan (IPP), including resourcing and budget. Drive lifecycle management (LCM) to extend product value and optimize portfolio performance, with a focus on broader label and indication expansion opportunities beyond current approved use. Lead the strategic development of the new VEXAS indication, including shaping the global program architecture from early planning through regulatory submission and launch.

Ensure readiness of global regulatory submissions and approvals for myelofibrosis label expansion and VEXAS indication. Align evidence generation plans with asset strategy, guiding clinical, medical, and real-world data priorities to support label expansion and indication expansion efforts. Assess ex-U.S. markets to identify viable pathways and develop focused geographic expansion plans, building a truly global footprint for Vonjo.

Engage and build relationships, in coordination with Medical, with select top-tier KOLs to inform the strategy. Cross-Functional Orchestration Lead and develop the Core Asset Team (CAT), integrating expertise from R&D, Medical Affairs, TechOps, Commercial, and Project Management. Partner closely with regional and functional leaders to align global strategy with local execution. Ensure effective coordination between CAT members and their respective functional asset teams to execute functional plans.

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Collaborate closely with executive leadership and cross-functional teams across R&D, Medical Affairs, Market Access, Regulatory, TechOps, and Commercial to ensure strategic alignment and execution. Operational Excellence Build the investment cases and ensure budgets remain within approved guardrails. Coordinate and oversee CAT members' strategy execution, leveraging functional expertise. Prepare for and represent the asset in ExCom Portfolio Reviews and other key decision forums.

Lead proactive scenario and mitigation planning to manage strategic, regulatory, and commercial risks impacting asset value. Identify risks and implement corrective actions early, escalating to governance committees as needed. Maintain a single source of truth for asset data and performance metrics. Market & Commercial Focus Partner with U.S. and regional teams to ensure launch readiness, assess ex-U.S. market potential, and maintain consistent launch excellence where applicable.

Collaborate with Insights & Analytics to inform strategy and pre-launch planning. Translate market insights into actionable strategies for differentiation and growth. Foster a culture of accountability, collaboration, and scientific excellence. Qualifications Master's degree in a relevant field (science background strongly preferred). 10+ years in global biopharma leadership, ideally in hematology and/or rheumatology.

Proven track record in lifecycle management, global asset strategy, and launch leadership. Strong cross-functional leadership and stakeholder management skills. Strategic thinker with disciplined execution and sound business judgment. Skilled communicator and influencer across senior levels. Culturally agile, with experience across U.S., Europe, Middle East, LATAM, and other international business environments. Fluent in English; additional languages a plus.

Compensation and Total Rewards at Sobi At Sobi, we are dedicated to providing our employees with a comprehensive and industry-competitive total rewards package. Our compensation philosophy is designed to recognize and reward talent, ensuring that your contributions are valued and reflected in your overall rewards. Your total compensation at Sobi goes beyond just your base salary and annual bonus. It also includes a robust suite of benefits, such as: A competitive 401(k) match to support your financial future.

Tuition and wellness reimbursements to invest in your personal and professional growth. A comprehensive medical, dental, and vision package to prioritize your health and well-being. Additional recognition awards to celebrate your achievements. The base salary range for this role is $210,000 – $270,000. Each individual offer will be determined based on several factors, including your experience, qualifications, and location.

Additionally, this role is eligible for both short-term and long-term bonuses, as outlined in the plan details. All Sobi employees need to demonstrate behaviors in line with Sobi's core values: Care, Ambition, Urgency, Ownership and Partnership. Are you ready to be on the Sobi team? Come join a culture that empowers every person to be the person that makes a difference for rare disease. Why Join Us? We are a global company with over 1,900 employees in more than 30 countries and are committed to the societies where we operate.

With a deeply skilled management team directing our day-to-day wins, and a Board with a stellar track record, we’re ready to take on the world’s diseases, ailments and adversity. Our people believe they have the power to make a positive impact in others’ lives because that’s exactly what we do here. If you’re seeking a career that taps into your talents in a way that makes the world a better, healthier place, we just may have a job for you.

We know our employees are our most valuable asset, and our culture conveys that. We offer a competitive benefits package, to support the health and happiness of our staff. Sobi Culture At Sobi, we refuse to accept the status quo. This is because we have witnessed first-hand the challenges facing those affected by rare diseases, and have used this knowledge to shape our business to find new ways of helping them. As a specialized biopharmaceutical company, we are dedicated to rare diseases.

And we see this focus as a strength. By effectively turning our research into ground-breaking treatments, we help make medicine more accessible and open up more possibilities for patients and more opportunities for those caring for them. This has been our approach since day one, but we know we can’t change the world of rare diseases on our own. Accomplishing this requires strong partnerships with patients, partners and stakeholders across the entire value chain.

Together, we define how our business can create solutions that serve the needs of those affected by rare diseases while facilitating sustainable growth. An Equal Opportunity Employer Sobi is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. All employment decisions at Sobi are based on business needs, job requirements and individual qualifications, without regard to race, color, religion or belief, national, social or ethnic origin, sex (including pregnancy), age, physical, mental or sensory disability, HIV Status, sexual orientation, gender identity, protected veterans and/or expression, marital, civil union or domestic partnership status, past or present military service, family medical history or genetic information, family or parental status, or any other status or protected groups by the laws or regulations in the locations where we operate.

If you are a qualified individual with a disability or a disabled veteran, you may request a reasonable accommodation if you are unable or limited in your ability to use or access this website to apply for a vacancy as a result of your disability. You can request reasonable accommodations by sending an email to [email protected] . Know Your Rights At Sobi, we believe diversity drives innovation and inclusion creates stronger teams.

We are committed to building a workplace where everyone feels valued and empowered to contribute. If this role excites you but you’re unsure if you meet every requirement, we encourage you to apply. Your unique perspective and experiences could be exactly what we need. We look forward to hearing from you! At Sobi, each person brings their unique talents to work as a team and make a difference. We are dedicated to developing and delivering innovative therapies to improve the lives of people who live with a rare disease.

Our edge comes from our team of people and our commitment to patients. Our mission and culture at Sobi North America get us excited to come to work every day, but here are a few more reasons to join our team: Competitive compensation for your work Generous time off policy Opportunity to broaden your horizons by attending popular conferences Emphasis on work/life balance Collaborative and team-oriented environment Making a positive impact to help ultra-rare disease patients who are in need of life saving treatments

Source listing: smartrecruiters_sobi

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