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USA remote

Senior Director, Patient Reported Outcomes

Revolution MedicinesRemote (United States)Posted 1 Sept 2026

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About this role

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients. The Opportunity: The Senior Director, Patient-Reported Outcomes (PRO) provides scientific and strategic expertise for the integration of patient-centered outcomes into clinical development programs. This individual serves as a key PRO subject matter expert and leads the development and execution of PRO strategies for assigned programs in support of clinical development, regulatory, market access, and scientific communication objectives.

Working closely with Clinical Development, Biostatistics, Regulatory Affairs, Medical Affairs, Clinical Operations, and other cross-functional partners, the Senior Director will translate patient-centered evidence needs into practical study plans and deliverables from development through registration and lifecycle management. This role is initially an individual contributor position with the opportunity to assume people-management responsibilities as the organization grows.

Key responsibilities include: Develop and lead PRO strategy for assigned clinical development programs, ensuring alignment with clinical, regulatory, and market access objectives. Recommend and support the selection, implementation, validation, and interpretation of PRO measures and patient-centered endpoints, including fit-for-purpose assessment of existing instruments. Partner with cross-functional teams to incorporate PRO objectives and assessments into study designs, protocols, schedules of assessments, statistical analysis plans, regulatory documents, and publications.

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Plan and oversee qualitative and quantitative research activities supporting PRO evidence generation, including vendor and external expert management as appropriate. Provide methodological guidance on endpoint definitions, meaningful change thresholds, responder analyses, missing data, interpretation of results, and integration of PRO findings into benefit-risk assessment. Contribute PRO expertise to interactions with regulatory authorities and health technology assessment agencies and to regulatory submissions, briefing documents, and product-labeling discussions; engage external experts and patient stakeholders as needed.

Support the analysis, interpretation, and dissemination of PRO evidence through study reports, publications, presentations, and other scientific communications. Contribute to the development of fit-for-purpose processes, standards, and best practices for patient-focused drug development, and provide coaching or mentoring to colleagues as appropriate. Required Skills, Experience and Education: Advanced degree (eg, Ph.D., Sc.D., Dr.P.H., Psy.D., M.D., Pharm.D., M.P.H., M.S., or equivalent) in psychology, psychometrics, epidemiology, public health, health outcomes research, behavioral science, or a related discipline.

Candidate should possesses a minimum of 13 years of relevant experience in patient-reported outcomes, patient-focused drug development, health outcomes research, or a related field within the pharmaceutical, biotechnology, CRO, consulting, or academic environment; level will be commensurate with experience. Demonstrated experience developing and implementing PRO strategies for clinical development programs, preferably including late-stage studies and support for regulatory interactions or submissions.

Strong expertise in qualitative and quantitative PRO methodologies, including instrument selection and development, content validity, psychometric evaluation, meaningful change, and interpretation of treatment benefit. Working knowledge of global regulatory expectations related to patient-focused drug development and clinical outcome assessments, with the ability to apply guidance pragmatically to development programs.

Demonstrated ability to work effectively in cross-functional teams, manage multiple priorities, and influence decisions through clear scientific rationale and collaborative partnership. Excellent written and verbal communication and presentation skills, with experience translating technical PRO concepts for clinical, statistical, regulatory, and business audiences. Preferred Skills: Experience developing or implementing PRO strategy in oncology clinical development; experience in solid tumors, including lung cancer (particularly NSCLC), pancreatic cancer, or other RAS-driven malignancies is preferred.

Experience supporting Phase 2 and/or Phase 3 development programs and working with clinical trial teams on PRO operationalization, analysis, interpretation, and reporting. Experience working with external research vendors, consultants, academic collaborators, patient organizations, or other partners involved in patient-centered outcomes research. Experience contributing to regulatory or HTA interactions, scientific publications, or cross-functional capability-building activities related to PROs or clinical outcome assessments.

#LI-VN1 #LI-Remote The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location.

Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact [email protected] . Base Pay Salary Range $232,000 — $290,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines.

These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.

If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.

Source listing: greenhouse_revolutionmedicines

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